The management of the Venezuelan economy has been surprisingly incompetent and disastrous, despite sitting on the world's biggest oil reserves. Sanctions and embargo against Venezuela have accelerated the decline, with inflation bordering on hyperinflation, a collapsing economy and mass migration. There is much to dislike in the Venezuelan Government and its policy, and by the way in the opposition, too. But sanctions and embargo is the wrong policy, causing further suffering for the Venezuelan people. Recognizing a self-proclaimed president and supporting a bogus uprising is converting it into a farce. It is old US policy to treat its foes like this. But what the EU is doing, supporting this, is very difficult to understand. Now the Europeans can no longer just blame the Venezuelan Government. They have decided to take on shared responsibility for the suffering of the Venezuelan people.
The short answer is yes, very much so. And much more than it will hurt the EU or the US. Post-Soviet Russia is mainly a producer and exporter of oil, gas and raw materials. Just as Canada, Australia, Brazil, Chile and Venezuela. It has gone through a de-industrialisation after the dissolution of the Soviet Union and is now heavily dependent on imports of almost everything. It is the world sixth biggest economy, but it is too small to survive isolated. So sanctions will hurt a lot. But they may also have unintended consequences. Some of them could actually be quite interesting.